I can't say whether SAM-e works or not, but it does initially have an unpleasant side effect: for the first few days I took it, it gave me uncomfortable, though not debilitating, stomach cramps. You are supposed to take it on an empty stomach, and that may make it worse. After taking it a few times, the cramps seemed to subside, but I don't feel sure enough of the desired effects to keep taking it right now. I'm going back to St Johns Wort, which I haven't used in many years, and which I hope will have the same good effect it used to have.
SJW was initially really helpful, but after about a year or so, I began feeling worse again and went back on something prescribed, I think. Effexor?
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