Antihistamines with anti-depressant effects

Mary K., Benadryl seems to cause me to have depression after two or three days of taking a night time dose. However, I found on Wikipedia and some other sites that it is supposed to have an anti-depressant effect, because it is a serotonin re uptake inhibitor. I thought that was interesting. Sarah
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In the 1960s it was found that diphenhydramine inhibits reuptake of the neurotransmitter serotonin. This discovery led to a search for viable antidepressants with similar structures and fewer side effects, culminating in the invention of fluoxetine (Prozac), a selective serotonin reuptake inhibitor (SSRI). A similar search had previously led to the synthesis of the first SSRI zimelidine from chlorpheniramine, also an antihistamine.